THE ACTION OF 2-METHYL-4-AMINO-5-AMINO-METHYLPYRIMIDINE
نویسندگان
چکیده
منابع مشابه
Histological investigations on the liver-disturbing action of 2-methyl-4-amino-5-hydroxy-methylpyrimidine.
Abderhalden (1) injected the pyrimidine and thiazole moieties of thiamine in mice and rats with the object of investigating the biosynthesis of thiamine and observed the induction of running fits. Its cause was further proved to be the pyrimidine moiety, i.e., 2-methyl-4-amino-5-hydroxymethylpyrimidine (OMP). Makino and Sasaki (2) reported the induction of running fits after in jecting this com...
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In the title compound, C6H6ClN3O2, all non-H atoms are approximately coplanar [maximum deviation = 0.012 (4) Å]; an intra-molecular N-H⋯O hydrogen bond occurs between the amino group and the carbonyl group. In the crystal, mol-ecules are linked by N-H⋯N hydrogen bonds into supra-molecular chains propagated along [101].
متن کاملMethyl 2-amino-5-bromobenzoate
In the title compound, C(8)H(8)BrNO(2), the dihedral angle between the aromatic ring and the methyl acetate side chain is 5.73 (12)°. The mol-ecular conformation is stabilized by an intra-molecular N-H⋯O hydrogen bond, generating an S(6) ring. In the crystal, mol-ecules are connected by N-H⋯O inter-actions, generating zigzag chains running along the b-axis direction.
متن کاملMethyl 2-amino-5-chlorobenzoate
The title compound, C(8)H(8)ClNO(2), is almost planar, with an r.m.s. deviation of 0.0410 Å from the plane through the non-hydrogen atoms. In the crystal structure, inter-molecular N-H⋯O hydrogen bonds link the mol-ecules into chains along the b axis. An intra-molecular N-H⋯O hydrogen bond results in the formation of a six-membered ring.
متن کامل2-Amino-5-methyl-6-methylsulfanyl-4-phenylbenzene-1,3-dicarbonitrile
The dihedral angle between the planes of the two aromatic rings of the title compound, C(16)H(13)N(3)S, is 56.7 (3)°. The crystal packing is stabilized by inter-molecular N-H⋯N hydrogen bonds, which link the mol-ecules into chains along [11[Formula: see text]].
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ژورنال
عنوان ژورنال: THE JOURNAL OF VITAMINOLOGY
سال: 1959
ISSN: 0022-5398
DOI: 10.5925/jnsv1954.5.229